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KMID : 0606920230310030306
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Biomolecules & Therapeutics
2023 Volume.31 No. 3 p.306 ~ p.311
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Meclofenamate Suppresses MUC5AC Mucin Gene Expression by Regulating the NF-kB Signaling Pathway in Human Pulmonary Mucoepidermoid NCI-H292 Cells
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Ryu Ji-ho
Kim Kyung-il
Rajib Hossain
Lee Mi-Soon
Hong Jin-Tae
Lee Hyun-Jae
Lee Choong-Jae
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Abstract
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The current study aimed to reveal the potential effect of meclofenamate, a nonsteroidal anti-inflammatory drug, on the gene expression of airway MUC5AC mucin. Human pulmonary mucoepidermoid NCI-H292 cells were pretreated with meclofenamate for 30 min and stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. Thereafter, the effect of meclofenamate on the PMA-induced nuclear factor kappa B (NF-kB) signaling pathway was assessed. Meclofenamate inhibited glycoprotein production and mRNA expression of MUC5AC mucins induced by PMA by inhibiting the degradation of inhibitory kappa Bα (IkBα) and NF-kB p65 nuclear translocation. These results suggest meclofenamate suppresses mucin gene expression by regulating NF-kB signaling pathway in human pulmonary epithelial cells.
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KEYWORD
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MUC5AC, Pulmonary mucin, Meclofenamate
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